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Events and People Who Made History in the Year 165 AD
-- A pandemic known as the Antonine Plague breaks out in Rome after the Roman army returns from Parthia. The plague significantly depopulates the empire. Precise date unknown.
-- The Romans establish a garrison at Doura Europos on the Euphrates, a control point for the commercial route to the Persian Gulf. Precise date unknown.
-- Marcus Aurelius creates four legal districts (iuridici) in Italy (5 if Rome is included). Precise date unknown.
-- The philosopher Justin of Nablus is executed in Rome as a Christian. Precise date unknown.
-- Discourse to the Greek (Oratio ad Graecos), by the Syrian Tatian, is the first treatise on the evils of paganism in Christian literature. Precise date unknown.
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